Flash forward to January 16, 2026, when “Soprano” Jamie-Lynn Sigler delivered a touching cameo on “Good Morning America.” With a willing heart she opened up about her experience as an actress with multiple sclerosis (MS). Nearly 25 years after her diagnosis, Sigler discussed her significant new role as Dr. Laura Kaplan in the long-running drama series “Grey’s Anatomy.” That last character, living with MS, was designed specifically with Sigler in mind.
At the tender age of 20 years old, Sigler was diagnosed with MS while living out her dream starring in the hit series “The Sopranos.” She was embarrassed and afraid that revealing her condition would end her acting career, so she kept it hidden for 15 years. Now in her 40s, she’s found the strength to speak out, encouraging and helping others who are going through their own struggles like she did.
“My very first take, where I do say the words that ‘I have MS,’ was very emotional for me,” Sigler shared. The heartbreaking scene captures just one of many moments in Ebony’s still-ongoing journey towards acceptance and authenticity. In her role as Dr. Kaplan, she delivers a powerful line: “I have MS, so standing for long periods in the operating room just isn’t an option.”
Sigler’s motivation extends beyond her character. She’s the co-host of the “MeSsy” podcast – a joint venture with her fellow actress and MS warrior Christina Applegate. Together, they aim to portray a genuine representation of living with the disease and to encourage others to embrace their experiences.
To Sigler, this latest chapter of her career goes beyond acting to include empowerment and visibility. She hopes that her portrayal will connect with viewers and show them that you can live your truth with MS.
“To think back 25 years ago, when I was diagnosed and having to keep it a secret, thinking that if anybody knew that I had MS, that meant that I would never work again and to now be in a position where my having MS inspired a role in a storyline on a show like ‘Grey’s Anatomy,’ I never would have believed you.” – Jamie-Lynn Sigler
